Strength deficits in primary focal hand dystonia
Identifieur interne : 003179 ( Main/Exploration ); précédent : 003178; suivant : 003180Strength deficits in primary focal hand dystonia
Auteurs : Janey Prodoehl [États-Unis] ; Colum D. Mackinnon [États-Unis] ; Cynthia L. Comella [États-Unis] ; Daniel M. Corcos [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Cerebral Cortex (physiopathology), Dystonia, Dystonic Disorders (diagnosis), Dystonic Disorders (physiopathology), EMG, weakness, Electromyography, Female, Hand, Hand (innervation), Humans, Isometric Contraction (physiology), Male, Middle Aged, Muscle Weakness (diagnosis), Muscle Weakness (physiopathology), Muscle, Skeletal (innervation), Nervous system diseases, Reference Values, Strength, Torque, Wrist (innervation), Writer cramp, focal dystonia, muscle activation, writer's cramp.
- MESH :
- diagnosis : Dystonic Disorders, Muscle Weakness.
- innervation : Hand, Muscle, Skeletal, Wrist.
- physiology : Isometric Contraction.
- physiopathology : Cerebral Cortex, Dystonic Disorders, Muscle Weakness.
- Adult, Electromyography, Female, Humans, Male, Middle Aged, Reference Values, Torque.
Abstract
Cortical activation is reduced when patients with focal dystonia perform movements that do not induce dystonic posturing. This finding suggests that the cortical drive to muscles may in some circumstances actually be reduced not increased, as suggested by basal ganglia models of dystonia as a hyperkinetic disorder. The purpose of this study was to examine flexor and extensor strength at the wrist (a clinically affected joint) and elbow (a nonclinically affected joint) in 18 patients with primary focal hand dystonia compared to matched control subjects. We measured peak torque from maximum voluntary contractions, and agonist and antagonist muscle activation by means of surface electromyograms. Patients were significantly weaker than controls at both the elbow and wrist joints and in both flexors and extensors compared to controls. Peak elbow flexion torque was, on average, 14.4% lower in the dystonic compared to the control group, elbow extensor peak torque was 28.6% lower, wrist flexor peak torque was 17.4% lower, and wrist extensor peak torque was 20.7% lower. Strength did not differ as a function of clinical severity. Reductions in peak torque were accompanied by reduced agonist activation, although this finding only reached statistical significance at the elbow. The amount of co‐contraction of antagonistic muscles was not significantly different between the two groups. These results are discussed in the context of dystonia as a disorder resulting from dysfunction of basal ganglia output. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20623
Affiliations:
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Le document en format XML
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Mackinnon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Comella, Cynthia L" sort="Comella, Cynthia L" uniqKey="Comella C" first="Cynthia L." last="Comella">Cynthia L. Comella</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush Medical College, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Movement Sciences, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush Medical College, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Bioengineering and Physical Therapy, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-01">2006-01</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="18">18</biblScope><biblScope unit="page" to="27">27</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">03EB6F7C6D233321213AC7E8F0C0613A49395283</idno><idno type="DOI">10.1002/mds.20623</idno><idno type="ArticleID">MDS20623</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cerebral Cortex (physiopathology)</term><term>Dystonia</term><term>Dystonic Disorders (diagnosis)</term><term>Dystonic Disorders (physiopathology)</term><term>EMG, weakness</term><term>Electromyography</term><term>Female</term><term>Hand</term><term>Hand (innervation)</term><term>Humans</term><term>Isometric Contraction (physiology)</term><term>Male</term><term>Middle Aged</term><term>Muscle Weakness (diagnosis)</term><term>Muscle Weakness (physiopathology)</term><term>Muscle, Skeletal (innervation)</term><term>Nervous system diseases</term><term>Reference Values</term><term>Strength</term><term>Torque</term><term>Wrist (innervation)</term><term>Writer cramp</term><term>focal dystonia</term><term>muscle activation</term><term>writer's cramp</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonic Disorders</term><term>Muscle Weakness</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Hand</term><term>Muscle, Skeletal</term><term>Wrist</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Isometric Contraction</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Dystonic Disorders</term><term>Muscle Weakness</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term><term>Torque</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Crampe écrivain</term><term>Dystonie</term><term>Electromyographie</term><term>Main</term><term>Résistance mécanique</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cortical activation is reduced when patients with focal dystonia perform movements that do not induce dystonic posturing. This finding suggests that the cortical drive to muscles may in some circumstances actually be reduced not increased, as suggested by basal ganglia models of dystonia as a hyperkinetic disorder. The purpose of this study was to examine flexor and extensor strength at the wrist (a clinically affected joint) and elbow (a nonclinically affected joint) in 18 patients with primary focal hand dystonia compared to matched control subjects. We measured peak torque from maximum voluntary contractions, and agonist and antagonist muscle activation by means of surface electromyograms. Patients were significantly weaker than controls at both the elbow and wrist joints and in both flexors and extensors compared to controls. Peak elbow flexion torque was, on average, 14.4% lower in the dystonic compared to the control group, elbow extensor peak torque was 28.6% lower, wrist flexor peak torque was 17.4% lower, and wrist extensor peak torque was 20.7% lower. Strength did not differ as a function of clinical severity. Reductions in peak torque were accompanied by reduced agonist activation, although this finding only reached statistical significance at the elbow. The amount of co‐contraction of antagonistic muscles was not significantly different between the two groups. These results are discussed in the context of dystonia as a disorder resulting from dysfunction of basal ganglia output. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Prodoehl, Janey" sort="Prodoehl, Janey" uniqKey="Prodoehl J" first="Janey" last="Prodoehl">Janey Prodoehl</name></region><name sortKey="Comella, Cynthia L" sort="Comella, Cynthia L" uniqKey="Comella C" first="Cynthia L." last="Comella">Cynthia L. Comella</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Mackinnon, Colum D" sort="Mackinnon, Colum D" uniqKey="Mackinnon C" first="Colum D." last="Mackinnon">Colum D. Mackinnon</name><name sortKey="Prodoehl, Janey" sort="Prodoehl, Janey" uniqKey="Prodoehl J" first="Janey" last="Prodoehl">Janey Prodoehl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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